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CNN —Close relatives of people with treatment-resistant depression are nine times more likely to develop depression that also does not respond to traditional treatment, a new study found. For people with treatment-resistant depression, also known as TRD, standard treatments such as psychiatric therapy and antidepressants may not work well, if at all. Being aware that treatment-resistant depression runs in families can help with early treatment options, experts say. First-degree relatives of people with TRD, which include parents, siblings and children, were nine times as likely to develop treatment-resistant depression and were at high risk of all-cause death and death by suicide compared with relatives of people without TRD, the study found. “So, this is a very welcome study indeed and goes someway to addressing the massive underrepresentation of Asian people in studies.”
Persons: CNN —, ., Ta Li, Yang Ming, , Andrew McIntosh, McIntosh, Justin Paget, ” Li, Li, , ” McIntosh Organizations: Lifeline, CNN, Tung University, Centre, Clinical, Sciences, University of Edinburgh, Digital Locations: Taipei, Taiwan, Scotland, Europe, North America
Seven years in, Country Garden has invested 20 billion ringgit ($4.3 billion) in the project, Forest City said, a far cry from the initial $100 billion plan. "Seeing is believing," Forest City said in an email response. "The land plot itself is valuable," a Singapore-based bondholder of Country Garden said, while highlighting the complications of dealing with a local government joint-venture. Last month, Malaysia's central bank said local banks had limited exposure to Country Garden amid concern about its financial stress. Anwar, Malaysia's prime minister, has designated Forest City a "special financial zone" to attract investment, which Forest City said would help with its marketing.
Persons: Foo Gee Jen, Anwar Ibrahim, Anwar, Malaysia's, Yang Ming Han, Loh, Loh Wee Loon, I'm, Xinghui Kok, Xie Yu, Anne Marie Roantree, Lincoln Organizations: ISKANDAR PUTERI, Garden, Forest, Malaysian, Reuters, Thomson Locations: KUALA LUMPUR, ISKANDAR, Malaysia, Garden's, City, Johor, Singapore, Forest City, Malaysian, Forest, Loh Wee, China, Johor Sultan, Iskandar Puteri, Kuala Lumpur, Yantoultra, Hong Kong
U.S. manufacturing orders in China are down 40 percent, according to the latest CNBC Supply Chain Heat Map data. HLS expects most carriers to extend their West Coast rates until December 14, holding at $1,300-$1,400 per forty-foot equivalent containers (FEU). The 2M Alliance of Maersk and MSC has suspended almost half of its U.S. West Coast services for December. is also impacting Vietnam, which has been booming as a manufacturing hub as more trade moved away from China. Canceled ocean sailings bound for Vietnam are up 50% for December.
"As shipping lines reduce their vessel calls in the form of blank sailings, this reduces the capacity for outbound volumes. Sea-Intelligence wrote in its recent blank sailings report that it has detected some unannounced cancellations for the calendar-year period of weeks 42-52 in the past two weeks. "Blank sailings have been ramped up drastically on the Transpacific, but not so much on Asia-Europe," said Alan Murphy, CEO at Sea-Intelligence. On Asia-North Europe routes, Sea-Intelligence is only seeing an additional six blank sailings, and on Asia-Mediterranean routes an increase of four blank sailings. The weekly average of vessels waiting this week is 14, waiting for an average of 6.3 days.
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